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Cover samsung t 285 NIH’s axing of bat coronavirus grant a ‘horrible precedent’ and might break rule-Cover Batteria iPhone 8/6/6S/7-eswvmr
2020.05.07 18:03
NIHdeclined to comment on why it canceled the grant, which was in its sixth year. But inemails reviewedbyScienceInsider, Michael Lauer, NIH’s deputy director for extramural research, suggested the Wuhan laboratory had not “takenall appropriate precautions to prevent the release of pathogens” that were the focus of the project. NIH offered no further support for that statement, however, and Lauer referred to the notion of the pandemic virus escaping the lab simply as “allegations.” Researchers familiar with the laboratory are skeptical of claims of lax safety practices. intelligence agencies to produce firm evidence linking the virus to the lab, but key spy agencies have not confirmed any cover s8 spigen, DISNEY PARKS VERA BRADLEY Cover Samsung Galaxy S8 connection so far. intelligence community “concurs with the wide scientific consensus that the COVID 19 virus was not manmade or genetically modified.” The statement left open the possibility that an accidental release of a natural virus could have launched the pandemic. (Later today, Trump said he was confident the virus came from the Wuhan lab, but that he was “not allowed” to say why he believed that.) NIH’s move, which was first reported byPolitico, “is the most counterproductive thing I could imagine,” given the research’s relevance to understanding the custodia samsung a5 2016 unieuro current pandemic and avoiding future viral samsung galaxy tab a sm-t555 custodia outbreaks, says Gerald Keusch, a former director of NIH’s Fogarty International Center who is now with the National Emerging Infectious Diseases Laboratory at Boston University. “This is a horrible precedent.” (Keusch recently partnered with the canceled grant’s principal investigator to apply for a different NIH grant; they were unsuccessful.) Others fear the project has become a casualty of an overtly political attempt by the Trump administration to shift attention away from its own troubled response to the pandemic and blame China. For some 15 years, the grant’s principal investigator, Peter Daszak, president of EcoHealth Alliance, a New York City nonprofit, and his colleagues have collaborated with a leading Chinese virologist who studies coronaviruses that infect bats. The virologist, Shi Zhengli, is based at the Wuhan Institute of Virology (WIV), located in the city where researchers first identified SARS CoV 2. The team has worked to understand how dangerous virusesjump from bats to humans, and to develop tools that could help researchers create diagnostics, treatments, and vaccines for human outbreaks. Bat viruses are believed to be the ancestral source of both the virus that jumped to civets and then to humans, sparking SARS and the camel virus that led to Middle East respiratory syndrome. The exact path SARS CoV 2 might have taken from bats to humans remains a mystery. EcoHealth Alliance researchers have long collected blood, urine, feces, and oral and anal swabs from wild bats in China and elsewhere in an effort to solve such puzzles. The alliance’s grant from the National Institute of Allergy and Infectious Diseases, titled “Understanding the risk of bat coronavirus emergence,” was launched in 2014 and renewed for 5 years in 2019 after receiving an outstanding peer review score. custodia samsung duos s7562 During the first custodia samsung tab s28 pollici 5 years, Daszak, with NIH vetting and approval, provided Shi with $599,000 out miglior cover s8, DIESEL ONLY BRAVE Cover Samsung Galaxy S8 of a total of $3.1 million in grant funding to use lab sequencing techniques to identify custodia portafoglio samsung a5 2016 bat coronaviruses that were at high risk of jumping to humans. The grant has also supported blood testing of people who live near bat caves in southern China to see whether they carried antibodies indicating they had been infected with a bat coronavirus. In the grant’s next term, through 2024, the researchers were planning to do more human, wildlife, and lab based studies to pinpoint hot spots in southern China where the risk is highest for a bat coronavirus to jump to humans. “The reason our grant was renewed for 5 years is because our work is so important in helping prevent pandemics,” Daszak says. In its first 5 years, the grant produced a score of papers and advances, including genetic sequences of two bat coronaviruses that have now been used as lab tools to test the antiviral drug remdesivir, which has shown some promise as a custodia a libro samsung s6 edge treatment for COVID 19. Shi’s participation in the grant recently drew attention because she works at WIV, samsung a20e custodia a sprawling campus that includes one of China’s two biosafety custodia tablet samsung tab 4 10 pollici level 4 (BSL 4) laboratories, which handle the most dangerous pathogens. Shi and colleagues have collected some 15,000 biological samples in the field from bats, some of which harbor coronaviruses. In January, her team published the genetic sequence of a bat virus that shares 96.2% of its genome with SARS CoV 2 the closest relative of today’s pandemic virus yet found. The United States does not require BSL 4 containment for the coronaviruses Shi works with, and she did her grant funded research at WIV in a BSL 3 lab. Department of Stateofficials had, in 2018, raised concerns about safety and staffing at WIV’s then brand new BSL 4 lab. Tendays after that column appeared, Lauer wrote to Daszak, to announce that NIH was ending his institute’s grant “for convenience.” Asked to explain the phrase, NIH did not elaborate, but quoted its Grants Policy Statement’s termination section; it notes the agency can cancel a grant “to protect the public health and welfare from the effects of a serious deficiency.” That explanation has left Daszak befuddled. “I can’t imagine that a grant titled ‘Understanding the risk of bat coronavirus emergence’ could in any way be a danger to public health,” he says. “I would expect it to be entirely the opposite.” Wuhan lab safety questions NIH has not responded to an email asking how the grant’s funding posed a danger to public health and welfare. But in a 19 April email to Daszak, Lauer wrote of WIV: “It is in the public interest that NIH ensure that a [grant] sub recipienthas takenall appropriate precautions to prevent the release of pathogens that it is studying.” There is no scientific evidence that SARS CoV 2 originated in Shi’s collection of bat viruses at WIV, though researchers concede that such an escape can’t be unequivocally ruled out. The known bat virus closest to SARS CoV 2, although 96.2% similar, is at least 20 years removed from the pandemic virus in evolutionary time meaning that if it escaped from a laboratory, it would have taken decades for it to evolve into the virus that has now killed more than 230,000 people to date. One Nature Medicine paper further indicated that the pandemic virus shows no signs of having been engineered by scientists, another contention of conspiracy theorists. For one thing, although the researchers note that thoughthe virus binds to a human cellular receptor to initiate an infection, that interaction is not custodia samsung gt-s7390 optimal, “strong evidence that SARS CoV 2 is not the product of purposeful manipulation,” they write. James Le Duc, director of Galveston National Laboratory, where he runs a BSL 4 lab, trains scientists in biosafety from around the world including one who came from Shi’s lab. He says he visited WIV shortly before its BSL 4 laboratory opened in 2018, and has known Shi for several years and holds her in high regard. “I just hate to see a world class coronavirologist, who’s dedicated her life working with this, being scrutinized as the possible source,” says Le Duc, who sees no evidence for a lab spillover but does not rule out the possibility. Other researchers familiar with WIV and Shi’s work also are skeptical of claims that WIV was cover s8 3d, DETROIT TIGERS Cover Samsung Galaxy S8 unsafe. “You can never eliminate anything 100%, but everything that we know and everything that we know has happened in nature about emergence says this came out of nature,” Keusch says. Embassy in Beijing, working for USAID. He notes that they were written after a diplomatic visit by nonscientists. “I didn’t place an enormous amount of weight on the observations that were made because they were not part of a critical, standardized evaluation,” says Carroll, a virologist. government is also “throwing rocks at them.” And he worries the tensions will come at a high price when it comes to responding to COVID 19. “We would know a lot less were it cover s8 harry potter, DR GONZO RALPH STEADMAN LAS VEGAS Cover Samsung Galaxy S8 not for the fact that we’ve been working with these guys in Wuhan for years,” he says. “We were personal friends with them you know, you pick up the phone and talk to them. In cases of scientific misconduct or conflict of interest, NIH has wide latitude to cancel grant awards, notes Heather Pierce, senior director and regulatory counsel at the Association of American Medical Colleges. But NIH officials did not charge custodia samsung s6 edge oro Daszak with any wrongdoing in their email exchanges, and at one point they stated that he cover s8 personalizzate, DOLAN TWINS 6 Cover Samsung Galaxy S8 could continue all of the grant’s work except for custodia per samsung s3 neo amazon pieces planned for WIV. (Lauer later abruptly reversed that and told Daszak that NIH clear view standing cover s8 , DOBRE BROTHERS 2 Cover Samsung Galaxy S8 had canceled the entire grant.) What’s more, the language that NIH provided to ScienceInsider from its Grants Policy Statement, jammylizard custodia per samsung galaxy s3 citing the need “to protect the public health and welfare from custodia rigida samsung galaxy s2 the effects of a serious deficiency,” is superseded by a different regulation, says one longtime university research administrator who asked not to be identified. That regulation allows NIH to cancel an award midstream only in four situations, none of which appears to pertain in the current case, she says. “If this was my institution I would be talking to our counsel about pushing back on NIH hard.” Keusch says he is trying to mobilize colleagues to contest NIH’s action. custodia strass samsung grand prime “This is cutting off your amazon custodia samsung j3 2016 face to spite your nose,” he says. “This is the worst kind of thing that political interference can cause custodia j3 samsung in a democracy.” Daszak, meanwhile, says he is trying to engage NIH in hopes of charting a path forward. He says he asked on 27 April to speak with Lauer. Lauer has not responded…